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The SUSTAIN 6 trial, another key study, examined semaglutide's impact on cardiovascular outcomes in patients with type 2 diabetes

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The full scope at Ascend includes: Obesity and overweight with comorbidities - full workup, GLP-1 candidacy assessment, lifestyle integration Type 2 diabetes with weight management goals - GLP-1 medications often address both indications simultaneously Hypertension tied to weight - coordinated medication review and lifestyle work Dyslipidemia and metabolic syndrome - lipids often improve markedly with weight loss Prediabetes - HbA1c 5.7-6.4% range, where intervention can prevent progression Fatty liver disease (MASLD) - weight loss is the primary intervention

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Funding This work was supported by grants from the National Natural Science Foundation (81972259, 82273394), the Clinical Trials Fund from Nanjing Drum Tower Hospital and the Affiliated Hospital of Nanjing University Medical School (2024-LCYJ-PY-01), Suzhou Municipal Health Commission (SKYD2022034), and the discipline construction and support project (XKTJ-JD202006) of the Second Affiliated Hospital of Soochow University

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